On September 1, 1892, the Reds played their maiden fixture following an acrimonious split from Everton, running out 7-1 winners over Rotherham Town at Anfield.
And, just over 125 years on from that win, this significant milestone will be marked with special celebrations before and during their fifth Premier League outing of the 2017-18 season.
Anfield's Fan Zones will host live music and a 125-themed Q&A with club legends in the build-up to the match.
There will also be a special mosaic displayed prior to kick-off, LFC Foundation activities at half-time, and other commemorative touches at the Reds' home ground.