Steven Gerrard's side are unbeaten in the division so far this season and will hope to continue their fine form on Teeside.
The U18s last played in the league on October 21 when they enjoyed a thumping 5-2 win over West Bromwich Albion in Kirkby.
Read on for all the details you need about the fixture...
Where is the game being played? The match is at Rockliffe Park, with kick-off set for 11am GMT.
How can I watch the game? We will have extended highlights available on LFCTV and LFCTV GO on Monday. Click here for details on how to sign up now.
Last meeting: Back in September the young Reds beat Middlesbrough 4-3 at the Kirkby Academy in the Premier League U18 Cup, with Liam Millar netting a hat-trick.