Neil Critchley's side are five points clear at the summit of the division and produced a convincing display to beat second-placed Everton 4-0 last Saturday.
The young Reds have also scored the most goals in PL2 so far, firing 22 in 10 games and conceding only eight.
Here's everything you need to know ahead of Saturday's trip to Chelsea...
Where is the game being played? The match is taking place at Cobham, Chelsea's training ground, with kick-off set for 2pm GMT.
How can I watch the game? Extended highlights will be available on LFCTV GO on Monday. Click here for details on how to sign up.
Last season head-to-head: In the away fixture Chelsea won 4-1, despite a brilliant goal from Harry Wilson. In the return fixture at Prenton Park back in March, the U23s got their revenge winning 2-0. Wilson netted the opener and Trent Alexander-Arnold curled home a fantastic free-kick.
Free video: Trent's stunning Chelsea free-kick
View from the manager, Neil Critchley
"I was really proud of the boys during our win over Everton last weekend. I thought they were excellent from start to finish and we caused them a lot of problems.
"We scored some great goals and the finish from Rhian Brewster when he was picked out superbly by Herbie Kane was just a fantastic goal.
"We have played some excellent football this season and it's no more than the boys deserve because we have got quality and ability - we see that every day in training.
"We face another tough test against Chelsea but hopefully we can maintain our high standards and perform well."