Steven Gerrard's side secured a dramatic 2-1 win over the young Black Cats in the league last week, and will be aiming for another victory over the north-east outfit at the Kirkby Academy.
The U18s have started Group D in fine style, sealing a thrilling 4-3 victory over Middlesbrough in their opener and thrashing West Ham United 6-0 away from home in their last game in the competition.
The young Reds will need to top their section to ensure a place in the quarter-finals.
The two best second-placed teams in the six groups will claim a last-eight berth, too.
Sunderland have also won their opening two games, so the victors of this tie will advance to the quarter-final.
Read on for all of the details you need about the U18s' next fixture...
Where is the game being played? The match is at the Kirkby Academy with kick-off set for 12.30pm GMT.
How can I watch the game? Extended highlights will be available on LFCTV GO on Monday. Click here for details on how to sign up.
Last meeting: Gerrard's charges clinched a 2-1 victory over Sunderland last week in the league with goals from Glen McAuley and a last-gasp winner from Curtis Jones. Watch highlights from that encounter below on LFCTV GO.