Steven Gerrard’s side set up a fourth-round meeting with the Gunners courtesy of a 5-1 success against Hartlepool United in the previous stage.
The young Reds have the opportunity to play at the first-team stadium for the one-off tie, with kick-off set as 3pm GMT.
The U18 Premier League clash with Newcastle United originally scheduled for the same date has therefore been switched to Saturday March 31.