This will be the first experience of playing at the first-team stadium for Steven Gerrard's side, and an exciting tie is in prospect.
Read on for more details about the fixture...
Where is the game being played? The match is at Anfield, with kick-off set for 3pm GMT.
How can I watch? Admission to the Kop is priced at just £3 for adults and £1 for juniors, young adults and over 65s. Season ticket holders and members can gain admission free of charge but need to secure their ticket in advance online. Click here to buy your tickets.
We will have delayed coverage of the full match on LFCTV on Saturday at 7pm. Highlights will also be available on LFCTV GO. Click here to find out more.
The road to the fourth round: Liverpool beat Hartlepool United 5-1 away in the third round, with Liam Millar netting a hat-trick. Arsenal, meanwhile, recorded a 2-1 victory over Sheffield Wednesday.
View from the manager, Steven Gerrard:
"These players will never get a better stage than on Saturday to play at Anfield. Hopefully we will get a decent turnout to watch the lads, the surface is incredible and it's what dreams are made of. When you grow up you want to play in big stadiums and there's none better than Anfield. It's such an iconic stadium. The lads should be licking their lips with this opportunity."