The top two sides in the group qualify for the next stage of the competition and, with just two games remaining, things are tight at the top.
Neil Critchley's side sit at the summit of Group G on goal difference ahead of Stoke City and Bristol City - all three sides have seven points.
After last week's 1-0 defeat away to Tottenham Hotspur in Premier League 2, the young Reds will be hoping to get back to winning ways.
Read on for more details on tonight's encounter...
Where is the game being played? The match is taking place at Ashton Gate with kick-off set for 7pm GMT.
How can I watch the game? We will have highlights on LFCTV and LFCTV GO later in the week. Click here to sign up now.
Last meeting: Back in November, Liverpool U23s beat Bristol City 7-0 in Chester. Danny Ings scored four times and Yan Dhanda, Conor Masterson and Harry Wilson were also on the mark.