Steven Gerrard's charges have lost their last two games in the league and will be out to get back on track when they return to home turf in Kirkby.
Liverpool U18s are currently third in the table and a win would see them go just one point behind leaders Manchester United.
Read on for more details about the U18 Premier League fixture...
Where is the game being played? The match is at the Academy in Kirkby, with kick-off set for 12pm GMT.
How can I watch? The game is live on LFCTV and LFCTV GO, with our coverage starting at 11.30am. Click here to sign up now.
View from the manager, Steven Gerrard...
"It's another opportunity for the boys. Our form hasn't been good of late; I won't shy away from that and take the responsibility for that, but at the same time my players have got to come with me and they have got to take responsibility as well.
"In terms of personnel against Wolves, I don't know at this stage what group of players I will be able to select from. We will sit down and decide because there is also an U23s game on Sunday.
"Whatever group of players we have we will prepare them as always to try and get a win. I think it's important we do try and stop the rot, if you like. This is Liverpool Football Club and Wolves are coming to town. We should have enough on the football pitch to go and beat them, so my job is to prepare them and put them in the best place to try and do that.
"In our last league game we completely dominated Everton but we found ourselves 3-0 down after 25 minutes. I'm not one to point fingers and dig people out, but the players know what was responsible for that and I've got to look at what the team gave as a whole. In terms of possession and chances created we were much better than Everton but we lost the game, so myself and the players have to take responsibility for that and we need to make sure that doesn't happen again in the future.
"Individuals have to stand up and be counted and try and avoid making stupid mistakes because we look back at all our goals we've conceded this season and the majority of them are individual errors that we need to avoid, because if you keep making them you make your job a heck of a lot harder."
View from the player, Glen McAuley
"It's a massive game for us after losing four in a row [at U18 level], so we need to get back to winning ways and hopefully Saturday we will do that.
"We've got to stop those little stupid mistakes which are letting us down and we need to put that to one side and make sure we are solid. We have definitely got goals in this team. All our attackers can score goals, so we just need to cut out our silly mistakes.
"Wolves are a tough, big, physical team to play against and they are also good on the ball, so we need to start quickly and be on top of our game.
"I think we will have a young team out because there's an U23s game on Sunday, so the young boys will come in and step up. As a second-year player I feel I've got a big part to play in leading these young boys and making them feel comfortable in our squad.
"On a personal level I would say it has been an OK season but not the best because I have had a few injuries. I'm feeling good now and I want to do my job and help this team and try and finish top scorer again this season."