Neil Critchley's side remain top of the divison but the second-placed Foxes have the same points total and goal difference.
The Reds have scored more goals than Leicester, however, and also still have a game in hand.
Read on for more details ahead of a crucial encounter...
Where is the game being played? The match is at the King Power Stadium with kick-off set for 7pm GMT.
How can I watch the game? The game is live on LFCTV and LFCTV GO, with our coverage starting at 6.30pm. Click here to sign up now.
View from the manager, Neil Critchley
"We face an important five days in Premier League 2 with two really important games. Leicester City gave us a really tough game early on in the season at Prenton Park and we know they will be physical, well organised and hard to play against.
"It is a fantastic opportunity for the young boys to play at the King Power Stadium on a decent pitch and it has the prospect of being a really top game for us to play in. It's a lovely stadium with a lovely pitch and we are really excited by the challenge and the week that lies ahead for us.
"Leicester's coach, Steve Beaglehole, is a really good coach who has been coaching for many years and he is extremely good at what he does. His team reflect him and they have some pace and power in their team.
"We had a really close game with them at Tranmere which was decided by a last-minute winner, and hopefully it's a similar game this time only for the winning goal to go in our favour!
"It's a great week for the boys to look forward to with a trip to the King Power being followed by Manchester United at Anfield on Friday night.
"Our message to the boys is accept the challenge, let's meet it head on and give it everything we have got. Let's keep a cool head but compete and make sure we play our game as well. We've got to make sure we stick to our style and our principles."
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