With two games remaining in the U18s Premier League, Steven Gerrard's side hope to clinch the runners-up spot.
United won the northern division last weekend after a win over Manchester City, and will now meet southern champions Chelsea in the national U18 final.
Read on for more details about tonight's fixture...
Where is the game being played? The match is at the Kirkby Academy with kick-off set for 7pm BST.
How can I watch? We are showing the full 90 minutes live on LFCTV and LFCTV GO, with our coverage starting at 6.30pm. Click here to sign up now.
Previous meeting: Back in December the two teams played out a 2-2 draw at The Cliff with United netting a 94th-minute equaliser. Adam Lewis was sent off for the Reds and Liam Millar and Glen McAuley were both on the mark.
In February, Gerrard's U19s squad beat United in the last 16 of the UEFA Youth League at Prenton Park, thanks to a goal from Ben Woodburn and a stunning strike from Rafael Camacho.
View from the manager, Steven Gerrard
"It's a special fixture. It's a great challenge for the lads but I do like driving in here on a Friday afternoon and seeing the cameras getting set up and the lights go on for a night game. As a kid, that's got to float your boat in front of LFCTV. The chance to go and challenge yourself against United, that's surely got to get your juices flowing."