With new manager Barry Lewtas at the helm, the young Reds kick-off the new campaign with a trip to Sunderland a week previous to the clash with United.
The first mini-derby of the season versus Everton is scheduled to be at the Academy on Friday November 2, while Lewtas' side are set to end their league season at home to Middlesbrough on Saturday April 27.
As well as competing in the U18s Premier League, the U18s will also take part in the Premier League Cup this term. The club's U19 group will again feature in the UEFA Youth League.
U18s' 2018-19 fixtures
August
Saturday 11 - Sunderland (A) - 11am BST, at the Academy of Light.
Saturday 18 - Manchester United (H) - 11am, at the Academy.
Saturday 25 - West Bromwich Albion (H) - 11am, at the Academy.
September
Saturday 1 - Stoke City (A) - 11am, at Clayton Wood Training Ground.
Saturday 15 - Newcastle United (H) - 1pm, at the Academy.
Saturday 22 - Blackburn Rovers (A) - 11am, at Blackburn Rovers Academy.
October
Saturday 6 - Manchester City (H) - 11am, at the Academy.
Saturday 20 - Wolves (A) - 12pm, at Sir Jack Hayward Training Ground.
November
Friday 2 - Everton (H) - 7pm GMT, at the Academy.
Friday 23 - Derby County (H) - 7pm, at the Academy.
December
Saturday 1 - Middlesbrough (A) - 11am, at Rockliffe Park Training Ground.
January
Saturday 5 - Manchester United (A) - 11am, at Aon Training Complex.
Friday 11 - Sunderland (H) - 7pm, at the Academy.
Saturday 19 - West Bromwich Albion (A) - 11.30am, at the West Brom Training Ground.
February
Friday 1 - Stoke City (H) - 7pm, at the Academy.
Saturday 23 - Newcastle United (A) - 11am, at Newcastle United's Training Centre.
March
Saturday 2 - Blackburn Rovers (H) - 11am, at the Academy.
Saturday 16 - Manchester City (A) - 11am, at City Football Academy.
Saturday 30 - Everton (A) - 11am, at Finch Farm.
April
Saturday 6 - Wolves (H) - 12pm BST, at the Academy.
Saturday 13 - Derby County (A) - 12pm, at Derby County's Training Centre.
Saturday 27 - Middlesbrough (H) - 12.30pm, at the Academy.