Barry Lewtas' side were handed a home tie with United in Friday's draw for the last eight.
The young Reds reached this stage in style, beating Stoke City 4-2, Reading 6-0 and Southampton 3-0 in the group stage.
Liverpool U18s will host Manchester United in the quarter-finals of the Premier League Cup.
Barry Lewtas' side were handed a home tie with United in Friday's draw for the last eight.
The young Reds reached this stage in style, beating Stoke City 4-2, Reading 6-0 and Southampton 3-0 in the group stage.