The young Reds then face Stoke City at the Academy on Saturday August 17, while the first mini-derby of the season versus Everton is scheduled to be played away on Saturday October 5.
The U18s' final match sees them welcome defending champions Derby County to Kirkby on April 25.
Barry Lewtas' side will also defend their FA Youth Cup title this term, as well as compete in the Premier League Cup. An U19 side is set to feature in the UEFA Youth League.
Supporters should note dates and venues of games are subject to change.
U18s' 2019-20 fixtures
August
Saturday 10 - Blackburn Rovers (A): 11am BST, at Blackburn Rovers Academy.
Saturday 17 - Stoke City (H): 11am, at Kirkby Academy.
Saturday 24 - Wolverhampton Wanderers (A): 12pm, at Sir Jack Hayward Training Ground.
Saturday 31 - Manchester United (H): 11am, at Kirkby Academy.
September
Saturday 14 - Manchester City (A): 11am, at City Football Academy.
Saturday 21 - Middlesbrough (H): 12.30pm, at Kirkby Academy.
October
Saturday 5 - Everton (A): 11am, at Finch Farm Training Complex.
Saturday 19 - Newcastle United (H): 1pm, at Kirkby Academy.
November
Saturday 9 - West Bromwich Albion (A): 11.30am GMT, at WBAFC Training Ground.
Saturday 30 - Sunderland (H): 12.30pm, at Kirkby Academy.
December
Saturday 7 - Derby County (A): 12pm, at Derby County Training Ground.
January
Saturday 4 - Blackburn Rovers (H): 11am, at Kirkby Academy.
Saturday 11 - Stoke City (A): 11am, at Clayton Wood Training Ground.
Saturday 18 - Manchester United (A): 11am, at Aon Training Complex.
February
Saturday 1 - Wolverhampton Wanderers (H): 12pm, at Kirkby Academy.
Saturday 22 - Manchester City (H): 11am at Kirkby Academy.
Saturday 29 - Middlesbrough (A): 11am, at MFC Training Ground.
March
Saturday 14 - Everton (H): 11am, at Kirkby Academy.
Saturday 21 - Newcastle United (A): 11am, at Newcastle United Training Ground.
April
Saturday 4 - West Bromwich Albion (H): 11.30am, at Kirkby Academy.
Saturday 18 - Sunderland (A): 11am, at Academy of Light.
Saturday 25 - Derby County (H): 12pm, at Kirkby Academy.