The tie had originally been scheduled to take place at the Totally Wicked Stadium in St Helens.
Barry Lewtas' team are level at the top of their group with two games left to play. The corresponding game in Napoli ended in a 1-1 draw.
A limited number of tickets for the fixture will be available only to Liverpool supporters and are on sale now here.
These must be booked online and in advance on a first come, first served basis. Ticket sales will end at 1pm on Monday at the latest.
Tickets cost £3 adults and £1 concessions (juniors, young adults, over 65s).
Season ticket holders and LFC members can receive a free ticket but this must be booked in advance from the online allocation.
Disabled supporters wishing to attend the fixture should call 0151 264 2500.
Only supporters in possession of a valid ticket will be allowed access to the Academy where limited parking will be available.
Liverpool U19s will travel to FC Salzburg on Tuesday, December 10 for their final group game as they seek to make it through to the final 16 of the competition.