The 17-year-old opened the scoring in a fixture away at Newcastle United by gliding past five opponents before applying a clinical finish.
That solo effort beat Mohamed Salah's opener against RB Leipzig in the Champions League in our poll on Liverpoolfc.com.
Diogo Jota's drilled strike to secure a win at Wolverhampton Wanderers took third spot, while Sadio Mane claimed fourth with his goal past Leipzig.
Missy Bo Kearns' conversion for Liverpool FC Women during their draw with Blackburn Rovers Ladies completes the top five.
LFC Goal of the Month winners 2020-21
September: Mohamed Salah (v Leeds United)
October: Mohamed Salah (v Everton)
November: Mohamed Salah (v Atalanta BC)
December: Mohamed Salah (v Crystal Palace)
January: Mohamed Salah (v West Ham United)
February: Mohamed Salah (v Leicester City)
March: Mateusz Musialowski (v Newcastle United U18s)