The Brazilian has recovered from the thigh injury sustained at Watford on Monday night as the Reds pick the same side for the fourth successive game.
Adam Lallana and Daniel Sturridge are again on the bench.
Liverpool: Mignolet, Clyne, Lovren, Matip, Milner, Lucas, Can, Wijnaldum, Coutinho, Firmino, Origi. Subs: Karius, Moreno, Grujic, Sturridge, Alexander-Arnold, Lallana, Klavan.
Here's how Southampton line up...