Loris Karius, who last featured in the 4-0 home win over Arsenal before the international break, is set to start in goal, the manager confirmed at his pre-match news conference.
Klopp was also asked about any potential involvement for Philippe Coutinho against the La Liga side, with the Brazilian ‘fit and healthy’ in the build-up to the tie.
“I could [give you an idea], but I’m sure all the Liverpool supporters around the world are ready to wait another 24 hours,” the boss responded.
Mohamed Salah missed the team’s training session on Tuesday afternoon due to illness, having reported to Melwood but been sent home as a precaution.
However, Klopp is hopeful of the Egyptian playing a part, commenting to the media later that evening: “It should not be that serious. In this moment we expect him back tomorrow morning for normal training.”
Sadio Mane, who is set to serve a domestic ban following his red card at Manchester City on Saturday, is of course eligible to feature in European competition.
Sevilla coach Eduardo Berizzo named a 22-man squad for the journey to Merseyside, which does not include midfielder Johannes Geis or forward Nolito.
Of the starting line-up that faced Liverpool in the 2016 Europa League final 16 months ago, five are among the travelling party for only the second competitive meeting between the clubs.