The forward will begin a three-match ban against Burnley on Saturday following his red card against Manchester City at the Etihad last weekend.
However, Klopp feels with the likes of Philippe Coutinho and Alex Oxlade-Chamberlain to call upon, as well as Roberto Firmino’s ability to play on the left, the Reds will retain their considerable forward threat.
“We’ve known for a few days that Sadio will not play and it was clear before the season there will be moments when he cannot play, or should not play maybe in other games,” the manager said at his pre-match press conference.
“That’s how we reacted in building the squad so we have options, enough options. Roberto has already played left-wing, Phil can play there of course, Alex can play there and we have more options, so that’s all good.
“We can change the system, we can do a lot of things. It’s always difficult to replace top-class players in really good shape, but we did it last year at the end of the season when we had to play without him and in most of the games we did really well.”