The Senegal forward is back in the Reds’ attack after a three-game domestic suspension to join Roberto Firmino and Mohamed Salah.
Loris Karius and Trent Alexander-Arnold are the two other players drafted in by Jürgen Klopp for the fixture at the Otkrytiye Arena.
Liverpool: Karius, Alexander-Arnold, Matip, Lovren, Moreno, Henderson, Can, Coutinho, Salah, Mane, Firmino.
Subs: Mignolet, Wijnaldum, Milner, Sturridge, Klavan, Oxlade-Chamberlain, Flanagan.