The Reds' biggest ever victory on Tyneside came in April 2013 when they won 6-0, with Jordan Henderson (two) and Daniel Sturridge (two) among the scorers. Only Henderson, Sturridge and Philippe Coutinho remain at Anfield from that day.
There has not been a goalless draw in any of the last 62 league fixtures between the teams – a run dating back to February 1974 and a meeting at St James' Park.
Liverpool have scored 21 goals in their past 10 visits but have not hit the net in the last two trips to the north east.
They have scored 88 goals against Newcastle in the Premier League era (more than against any other team) and 138 have been scored in total, with only the Reds' fixtures against Arsenal (141) and Tottenham Hotspur (140) producing more.
And they have fired 36 league goals at St James' Park – more than they have netted at any other away ground in the Premier League era.
The Reds' next goal will be their 100th scored at Newcastle in the league.
Mohamed Salah played the first game of his career in English football against the Magpies – as a substitute in a 3-0 home league win for Chelsea in February 2014.
Joel Matip is the only Liverpool player to appear in every minute of league football this season.
Henderson could play the 250th game of his Liverpool career.
Sturridge could score the 100th goal of his club career; 61 of his previous 99 goals have come during his time at Anfield.
The Reds have 11 points from six games this campaign – one point more than they accumulated from the corresponding fixtures last season.
Liverpool are five goals short of recording 150 in the Premier League under Jürgen Klopp. This is his 75th game in charge.
This will be the first time in five clashes between the clubs that both managers have remained unchanged from the previous meeting.