The Reds captain limped off just 10 minutes into the game against Arsenal on Friday night, replaced by James Milner in a match that ended in a 3-3 draw at Emirates Stadium.
And Jürgen Klopp confirmed that Henderson’s injury will sideline him for the visit of the Swans to Anfield at a minimum.
“The problem is that Hendo will not feature for sure, he is out,” the manager said.
“That makes it even worse, the feeling of [the result at Arsenal], because so far we were really OK with this kind of injury and now it happened in the middle of the [busy] period, or whatever.
“[It’s] not too cool but I heard nobody else [is injured], a few knocks as it always is, but they should be OK again. That’s the situation.”