The Reds' 5-0 victory in the first leg at the Estadio do Dragao took this season's tally in continental competition up to 34 goals - equalling the benchmark set by Rafael Benitez's side in 2007-08.
Benitez's team played 14 games to reach the semi-finals that season, while Jürgen Klopp's men have played nine matches so far this term.
For more need-to-know pre-match facts and figures, courtesy of club statistician Ged Rea, read on...
Liverpool have never been eliminated from European competition after winning the first leg away from home, in 33 ties.
Qualification tonight will see the Reds reach their 24th European quarter-final and their 14th in Europe's premier club competition.
Liverpool are unbeaten in their last 11 games in the Champions League - winning six and drawing five.
Roberto Firmino has scored eight goals in Europe this season, one more will equal the club record set by Dean Saunders in the 1991-92 UEFA Cup campaign.
Mohamed Salah has scored in seven consecutive games for the Reds; should he net tonight he would equal the club record of eight set by Dick Forshaw in 1924-25 and John Aldridge in 1988-89.
Liverpool have lost only one of the last 18 European matches at Anfield and are unbeaten at home in the last 13, winning nine and drawing four.
In the first leg at the Estadio do Dragao, LFC became the first English team to score five goals in an away Champions League knockout fixture.
Porto need to score five unanswered goals at Anfield to force extra-time. The Reds have only ever conceded five goals in one European game - a 5-1 defeat at Ajax in the European Cup in December 1966.
Klopp's Reds have conceded just one goal in the last four games in all competitions and have kept four clean sheets in their last six matches.
FC Porto have never beaten Liverpool in five competitive meetings.
The Portuguese side have been drawn against English opposition on 18 previous occasions but have never won a match in England.
Liverpool have won seven of 10 home fixtures against Portuguese opponents, with only Benfica claiming victory (2-0) at Anfield, in 2006.