The midfielder could play his 200th Premier League match for the Reds if selected at Old Trafford.
The 27-year-old is one of only two men available today that were also part of the last LFC matchday squad to triumph at United - Henderson and Simon Mignolet helped secure a 3-0 win at Old Trafford in March 2014.
For more need-to-know pre-match facts and figures courtesy of club statistician Ged Rea, read on...
This will be the 200th meeting between Liverpool and United in all competitions.
The last four meetings between the clubs, home and away, have ended in a draw. There have never been five stalemates in succession.
Jürgen Klopp has lost just one of his eight matches as a manager against Jose Mourinho sides, winning three and drawing four.
Liverpool have scored at least twice in 14 of their last 16 games in all competitions.
Mohamed Salah has scored 26 times in his last 27 games for the Reds. If he finds the net today he will be the first LFC player ever to score in 20 Premier League games in a season.
Liverpool's last two wins at Old Trafford have come in the month of March - in 2009 (4-1) and 2014 (3-0).
The last 10 league meetings at Old Trafford have produced 34 goals.
The Reds have scored in eight of the last nine league visits.
Trent Alexander-Arnold made his first Premier League start for Liverpool at Old Trafford last season.
Current Reds duo Sadio Mane and Virgil van Dijk played in Southampton's 1-0 victory on this ground in January 2016.
Today's fixture brings together the team who have conceded the fewest home Premier League goals (United, six) and the team who have scored the most away top-flight goals (Liverpool, 34).