The Reds were beaten 2-1 by their rivals at Old Trafford six days ago, failing to overturn the deficit opened up by Marcus Rashford's first-half brace despite an improved showing in the second period.
Klopp has never overseen back-to-back Premier League defeats since taking the reins at Anfield, but he doesn't believe that record counts for much ahead of the clash with the Hornets.
He does, however, have plenty of faith in his players' desire to quickly make amends.
"First of all, [the record is] good news but it doesn’t mean anything, it only means we have to do it again," he told reporters.
"We expect from ourselves that we win football games, especially if we lost a game like the last one.
"In an ideal world you play three hours later and change your own mood, so we keep that kind of revenge feeling or whatever during the week because we have to and we want to go back immediately to the other side, the winning side."
The German went on to explain that he saw plenty of positives in the Reds' performance against Jose Mourinho's men, even if the result was not favourable.
And he hopes his squad can build on the good moments of a forgettable afternoon in Manchester by using the hurt of losing in the right way.
He added: "We were not happy about the result, we were not happy about the performance, but the performance was not as bad as the result.
"Only in a few minutes - seven or eight very decisive minutes - we deserved the result. We can play better than we played even in the good moments of that game and that's what we have to try.
"[There are] a lot of things you can learn from this game, a lot of things you have to learn from this game.
"It’s already a few days ago but without striking back in an overly aggressive way, because we never did that, we use it as motivation for sure.
"In professional sports you need to be a little bit angry to bring your best on the pitch.
"So, we respect the rules but we are [angry], and after a game like this it's a little bit more. Hopefully we can bring that in the game as well."