As domestic football resumes this weekend, the Reds are the first team in action when they face Crystal Palace at Selhurst Park tomorrow lunchtime.
A win in south London would move Karius and co 10 points clear of fifth-placed Chelsea, who on Sunday take on the team one position above them in the table: Tottenham Hotspur.
“It would give us [a] 10-point [lead], which is a good thing. It can’t be negative, a good result can only be positive,” the German told Premier League Productions.
“And of course it is also a little boost for the Manchester City game [in the Champions League]. But right now everyone is thinking about Crystal Palace. 10 points sounds good – so let’s do it.”
While Liverpool’s focus is consumed by the task at hand against Palace, who remain threatened by relegation despite a crucial win at Huddersfield Town before the international break, that Champions League quarter-final clash with Manchester City is looming into view too.
Pep Guardiola’s side visit Anfield for the first leg on Wednesday night and the clubs meet again to settle the tie six days later, with a Merseyside derby at Goodison Park in between.
“If you look at the Champions League, it’s all or nothing in the next two weeks,” said Karius.
“If you look at the Premier League, we have to get the results every week until the middle of May, not just these two weeks. There are two very important games in the Premier League. You have to win almost every week to stay up there – that’s what the [other] teams do.
“So it’s a big two weeks, but that’s what you play for so it’s exciting.”
Karius actually spent a couple of years with City as a youngster.
Sensing the pathway to senior opportunities might be blocked in Manchester, the ambitious goalkeeper sought a move to Mainz and his performances in the Bundesliga led to a Liverpool transfer.
But he recalls his time there with fondness nevertheless.
The No.1 added: “It was the right decision for me to leave.
“It was great for me to train with great players every day as a young player, and to work with Joe Hart back then; he was a great guy and a great role model.
“It was the right decision for me to go there but also to leave at the right time. At the time I left, it was good for me to play first-team football in Germany and then go to a big club like Liverpool again, so it all worked out.”