Amid an ear-splitting din created by the home supporters at Anfield, Salah opened the scoring in the 12th minute with a clinical finish from close range.
Oxlade-Chamberlain then sent a 25-yarder rocketing into the top corner of the Kop-end net before Mane made it three shortly after the half-hour mark with a header from a superb in-swinging cross by Salah.
Unsurprisingly, City came on strong in the second period but the Reds - for whom Salah was forced off soon after the restart with an apparent muscle problem - defended stoically and will take a deserved lead to Etihad Stadium for next week’s second leg.
Take a look at a gallery of the best photos from an incredible night at Anfield below…
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