The Reds travel out to Italy on Tuesday afternoon ahead of the return meeting of the European tie, holding a 5-2 aggregate lead from the opening match at Anfield.
Sadio Mane makes the journey after missing the weekend draw with Stoke City while Adam Lallana joins the travelling party following a spell out with a hamstring injury.
Jordan Henderson and Trent Alexander-Arnold, who each had minor fitness concerns from the weekend, also travel to Rome.
Joe Gomez is not involved, however, having sustained an ankle issue on Saturday.
Liverpool squad: Karius, Clyne, Van Dijk, Wijnaldum, Lovren, Milner, Firmino, Salah, Henderson, Klavan, Moreno, Mane, Lallana, Mignolet, Robertson, Ings, Solanke, Jones, Ward, Woodburn, Masterson, Camacho, Alexander-Arnold.