The 20-year-old striker comes into the XI for a game from which the Reds need at least a point to secure Champions League qualification, as does Jordan Henderson.
James Milner is absent from the matchday squad as a precaution after a muscle issue, while Nathaniel Clyne drops to the bench.
Adam Lallana is among the substitutes having returned to full training last week.
Liverpool team: Karius, Alexander-Arnold, Lovren, Van Dijk, Robertson, Henderson, Wijnaldum, Mane, Salah, Firmino, Solanke.
Substitutes: Mignolet, Clyne, Klavan, Moreno, Lallana, Ings, Woodburn.