Lallana was forced to withdraw from international duty due to a groin strain and while the issue is not serious, it will keep him out of the Premier League encounter at Wembley.
Mignolet also came back early from the Belgium squad because of a hand injury, but has returned to full training at Melwood this week.
Jürgen Klopp told his pre-match press conference on Friday morning: “Simon is OK, he trained completely normally. We gave him the rest he needed with the finger issue. It is fine, he has trained normally, catching balls all fine.
“Goalies are pretty hard in that; they’re used to a little pain in their hands and fingers. He’s trained good.
“Adam is on a good way. It’s obviously not too serious but he is not available for the weekend and maybe not for the next week [and] then I hope he can be back.”