The defender is handed his first Premier League appearance of the season as he replaces Trent Alexander-Arnold in the back four.
Jordan Henderson is the other change to the starting XI, though Naby Keita is fit to take a place on the bench.
Liverpool: Alisson, Gomez, Lovren, Van Dijk, Robertson, Wijnaldum, Milner, Henderson, Mane, Salah, Firmino.
Subs: Mignolet, Fabinho, Keita, Sturridge, Shaqiri, Matip, Alexander-Arnold.