The Reds did the 'double' over David Wagner's Terriers last season, winning 3-0 at both Anfield and the John Smith's Stadium.
And should Klopp's side keep a clean sheet in the match, they will become the first Liverpool team ever to have conceded as few as three goals in the opening nine games of a league campaign.
The Reds' best in the Premier League era is five, under Rafael Benitez in 2007-08.
For more need-to-know pre-match facts and figures, courtesy of club statistician Ged Rea, read on...
Liverpool are unbeaten in the last 11 league meetings with Huddersfield home and away, winning eight and drawing three on a run that dates back to 1959.
The Reds edge the overall head-to-head in league clashes with 27 wins to 26. They have scored 119 league goals to the Terriers' 113.
Should LFC win at the John Smith's Stadium, Klopp's men will record 23 points from their first nine top-flight games of the season - a tally the Reds have equalled only once before in the Premier League era, in 2008-09.
If they avoid defeat, Klopp's side will have the best goal difference of any Liverpool team in the Premier League era after nine games. They are currently on +12 and the record after nine games stands at +11, which the club have recorded four times.
Liverpool have won four and drawn one of their last five league visits to the Terriers.
Against all opponents, the Reds have lost only three of their last 37 Premier League matches home and away.
Roberto Firmino's goal in last season's 3-0 away win was the 50th scored by the Reds in the league at Huddersfield.
Liverpool have never lost any of the 21 away matches in all competitions in which Firmino has netted (18 wins, three draws).
Mohamed Salah's next goal will be his 50th for an English club in all competitions.
Joe Gomez has played three times in his career against Huddersfield, the first with Charlton Athletic. Each time his team has won 3-0.
Andy Robertson could play the 200th league game of his career, having also featured for Hull City and Scottish sides Queen's Park and Dundee United.
Huddersfield have not won in the last 12 league games (five draws and seven defeats) and are enduring their longest winless run since 2000 when they went 17 games without a victory.