Mane is deemed fit to begin the contest having missed the weekend win at Huddersfield Town due to a hand injury and is one of five changes made by Jürgen Klopp.
Roberto Firmino is also restored to attack to join Mohamed Salah, while Fabinho and Georginio Wijnaldum are named in midfield alongside Xherdan Shaqiri.
Trent Alexander-Arnold is back in defence in place of Dejan Lovren.
Liverpool: Alisson, Alexander-Arnold, Gomez, Van Dijk, Robertson, Fabinho, Wijnaldum, Shaqiri, Mane, Salah, Firmino.
Subs: Mignolet, Lovren, Moreno, Milner, Lallana, Sturridge, Origi.