The game itself was an occasion to forget as Jürgen Klopp's side succumbed to a 2-0 defeat by the Serbian outfit at Rajko Mitic Stadium.
But the club has, of course, created rich history across the continent with eight final appearances and five triumphs.
Here are some key numbers from the Reds’ double-century of fixtures in the tournament…
376 – the total number of goals Liverpool have scored
177 – goals have been conceded by the Reds
113 – victories recorded
91 – appearances by Jamie Carragher, the most of any Liverpool player
87 – clean sheets have been achieved by the club
76 – is the highest number of games managed, by Rafael Benitez between 2004 and 2009
74 – the number of different clubs Liverpool have faced in the competition
30 – goals scored by Steven Gerrard, who tops the club’s all-time list
28 – goals scored by substitutes
27 – penalties have been awarded to the Reds, with 19 scored and eight missed
18 years and 59 days – is the age of Liverpool’s youngest ever player in the competition, Antonio Barragan
15 – games formed the Reds’ longest unbeaten run, between November 2014 and April 2018
11 – hat-tricks have been scored by the team
11-1 – is Liverpool’s record aggregate win, against Reykjavik in the 1964-65 preliminary round
10-1 – is the Reds’ biggest home victory, over Oulu Palloseura in October 1980
9 – wins in a row is their best run, between November 1983 and October 1984
7-0 – is Liverpool’s biggest away win, achieved against Maribor last season