The Reds, who hold a 2-0 lead from last week's first leg at Anfield, fly out to Portugal on Tuesday afternoon ahead of the tie at Estadio do Dragao.
Dejan Lovren misses out due to illness, while Alex Oxlade-Chamberlain remains at Melwood to carry out additional fitness work.
Liverpool squad: Fabinho, Van Dijk, Wijnaldum, Milner, Keita, Firmino, Mane, Salah, Gomez, Alisson, Henderson, Sturridge, Moreno, Lallana, Mignolet, Shaqiri, Robertson, Origi, Matip, Kelleher, Alexander-Arnold.