Match information
The game will be held at St Mary's with kick-off at 3pm BST.
How to follow
Listen to live commentary on the full 90 minutes here on Liverpoolfc.com. Steve Hunter and Nigel Spackman will call the action as it happens.
Get post-match reaction on LFCTV GO after the full-time whistle, with short match highlights available from 7pm BST.
Extended highlights will be published at midnight. Join LFCTV GO now and claim your first month for free.
The last meeting
A frantic Friday night contest between the sides in April saw title-chasing Liverpool emerge 3-1 winners.
Shane Long put Saints ahead but Naby Keita equalised before the break and late goals from Mohamed Salah and Jordan Henderson secured three points for the Reds.
What the managers say
“Southampton is a really strong side with a very specific style of play. We had enough time to analyse them, it’s just that we had to do it immediately after coming back from the other game. We saw two pre-season games and the game against Burnley, so we have all the informations we need. They didn’t play as bad as the 3-0 looks and they will still be full of desire and confidence."
Jürgen Klopp
"I want to see a reaction from the team that is really believing in what they are doing and stay on the track until the last minute. If we are like that then we are not so easy to beat."
Ralph Hasenhuttl
Stat
A win for Liverpool would secure an 11th successive Premier League victory and equal the club's record.
The officials
Referee: Andre Marriner
Assistants: Scott Ledger, Simon Long
Fourth official: John Brooks
VAR: Craig Pawson
Assistant VAR: Richard West