The goalkeeper has recovered from an ankle issue to take his place in the Reds’ starting line-up at St Mary’s.
In total, Jürgen Klopp makes three changes from the team deployed in the Super Cup final in midweek, with Trent Alexander-Arnold, Georginio Wijnaldum and Roberto Firmino restored to the XI.
Liverpool: Adrian, Alexander-Arnold, Matip, Van Dijk, Robertson, Wijnaldum, Milner, Oxlade-Chamberlain, Mane, Salah, Firmino.
Subs: Lonergan, Fabinho, Gomez, Henderson, Lallana, Shaqiri, Origi.