The Reds have won their last 12 Premier League fixtures and are one away from eclipsing the record set by Sir Kenny Dalglish's side between April and October 1990.
Three points at Turf Moor would also make Klopp's men the first ever Liverpool side to win each of their opening four fixtures in back-to-back league campaigns.
For more need-to-know pre-match facts and figures, courtesy of club statistician Ged Rea, read on...
Liverpool have won each of the last five away league games for only the fourth time in the Premier League era. Should they take maximum points today, they will equal the club record of six, which they have previously done on five occasions – the last being in 2014.
Another club record the Reds could equal today would be 10 away Premier League games without defeat, matching the sequence set from August to December last year.
Roberto Firmino will become the first Brazilian to score 50 Premier League goals if he nets against the Clarets. He would become the ninth Liverpool player to reach the milestone.
Should they win or draw, the Reds will be 21 league games undefeated, equalling their best run under Klopp.
James Milner has scored in 52 Premier League games in his career and never lost (41 wins, 11 draws) – a competition record.
The last Liverpool player to hit a hat-trick against Burnley was Yossi Benayoun, who did so in a 4-0 Anfield win back in September 2009.
Burnley's Dwight McNeil has recorded six assists in the Premier League in 2019. The only English player with more is Trent Alexander-Arnold (11).
Referee Chris Kavanagh has taken charge of the Reds three times in his career. They have won them all, the last of which was the Merseyside derby back in December.