If the forward scores at Anfield, it will be his 50th top-flight goal on his 100th Premier League appearance for the club.
Mane would also become the 10th different Liverpool player to score 50 goals in the competition - more than any other side.
The No.10 heads into the match in good form, too, having netted 16 goals in his last 14 Premier League starts at Anfield.
For more need-to-know pre-match facts and figures, courtesy of club statistician Ged Rea, read on...
Liverpool are unbeaten in eight home Premier League matches against Leicester.
However, the Foxes were the last team to prevent Jürgen Klopp's side from winning at Anfield in the league - earning a 1-1 draw in January this year.
Since that draw, the Reds have won 10 in succession at home, scoring 33 goals and conceding just six times.
Klopp's men are unbeaten in their last 43 home league games - Liverpool's second-longest run ever in top-flight history.
The club's record run at Anfield came from 1978 to 1981 when they went 85 games without defeat in all competitions - including a record 63 in the league - before the sequence was ended by Leicester.
Mohamed Salah has scored 49 times in 56 Anfield appearances and a goal today will see him reach 50 on home soil in fewer games than any other Liverpool player apart from Roger Hunt, who did it in 55.
Georginio Wijnaldum could play the 150th Premier League game of his career (the first 38 were with Newcastle United). It would also be his 100th Premier League start for the Reds.
Fabinho has not been on the losing side in any of the 27 league games he has started for Liverpool.
Since Brendan Rodgers was appointed Leicester manager in February, only Liverpool (49) and Manchester City (46) have won more Premier League points than the Foxes (31).
Jamie Vardy has scored seven of Leicester's last 11 goals against Liverpool. Only two players - Andy Cole (11) and Thierry Henry (eight) - have scored more against the Reds in Premier League history.