The Liverpool No.66 did not travel for the midweek victory at Genk due to illness but is on track to return this weekend.
Fellow full-back Andy Robertson is also ready to play after being substituted around the hour mark in Belgium on Wednesday.
The Reds must check on Joel Matip, who has been sidelined with a sore knee, while Xherdan Shaqiri is not yet available.
“Yeah, we just rested Robbo,” Jürgen Klopp explained at his pre-Tottenham press conference on Friday.
“We thought that’s enough for today [against Genk on Wednesday], 60 minutes. He could do it and did it. He is fine.
“Trent is fine. Or looked fine, if there is no setback. He was ill – ill enough to not travel with us, which is not a good sign, but yesterday he had a clearing session and if it is as it was yesterday then he should be fine.
“With Joel, we have to see. I didn’t see him yet. I don’t know 100 per cent.
“I saw Shaq this morning and spoke to him. It will take a little bit of time still. Big muscles, unfortunately, it needs a little bit longer to heal.
“All the other long-term [injuries] are not available.”