Joe Gomez and James Milner return to the defence, while Fabinho and Naby Keita come into midfield.
Divock Origi and Alex Oxlade-Chamberlain join Mohamed Salah in attack to complete the alterations to the team deployed at Aston Villa on Saturday.
Jordan Henderson misses out as he is recovering from a bout of illness.
Liverpool: Alisson, Alexander-Arnold, Gomez, Van Dijk, Milner, Fabinho, Wijnaldum, Keita, Oxlade-Chamberlain, Salah, Origi.
Subs: Adrian, Lovren, Firmino, Mane, Lallana, Robertson, Jones.