The Reds have won the last four Premier League meetings with the Eagles and Mane has scored in each of them - a club-record consecutive run against Palace.
No other Liverpool player in history has scored in more than two successive meetings with the south Londoners.
In 10 career games against the Eagles, Mane has scored seven goals - more than he has managed past any other side.
For more need-to-know pre-match facts and figures, courtesy of club statistician Ged Rea, read on...
In 20 Premier League clashes with the Eagles there have been 72 goals scored at an average of 3.6 goals per game, with Liverpool scoring in all but two of the meetings.
There have been just two goalless draws in all league fixtures between the teams - in April 1980 at Selhurst Park and in December 1994 at Anfield.
Joel Matip scored his first Liverpool goal in the 4-2 win at Selhurst Park in October 2016.
Andy Robertson made his debut for the Reds against Palace in August 2017.
Roberto Firmino's next top-flight appearance will be his 150th for the Reds in the Premier League.
Alex Oxlade-Chamberlain's next outing will be his 300th senior club game. He has scored four goals in his last three Liverpool starts (all in cup matches).
Liverpool are currently unbeaten in 14 away league games - their joint-third-longest away league run without defeat in history.
The Reds are unbeaten in their last 29 league games home and away (24 wins and five draws) - two shy of the club record of 31.
The team with the next longest current unbeaten run in the top flight is Wolverhampton Wanderers, with seven.
Liverpool go into this game having accumulated twice as many points or more than every other team outside of the Premier League top four.
In matches immediately following international breaks the Reds are unbeaten in the last nine, with seven wins and two draws. Four of those victories and a draw have come away from home.