The forward scored three goals and claimed one assist to help Liverpool to victories in all four of their league outings during the month.
Mane began November by scoring a dramatic 94th-minute winner at Aston Villa, just moments after teeing up Andy Robertson for the Reds’ equaliser in the 2-1 success.
He was also on target in the victories over Manchester City and Crystal Palace as Jürgen Klopp’s side ended the month eight points clear at the division’s summit.
The 27-year-old has won the prize on two previous occasions – August 2017 and March 2019.
Mane faces competition from Dele Alli and Son Heung-min (Tottenham Hotspur), Raul Jimenez (Wolverhampton Wanderers), Lys Mousset (Sheffield United) and Caglar Soyuncu and Jamie Vardy (Leicester City) this time around.
Fans can cast their vote for the Liverpool No.10 by clicking here.