A win in north London would take Jürgen Klopp's Reds up to 61 points and become the best-ever start to a season in English football's top tier after 21 games.
Pep Guardiola's Manchester City set the current benchmark of 59 points during the 2017-18 campaign.
Liverpool have taken 58 points from a possible 60 so far this term, winning 19 and drawing one of their 20 fixtures.
City had the same tally at the same stage of the 2017-18 season, but drew their 21st game of the campaign away at Crystal Palace.
For more need-to-know pre-match facts and figures, courtesy of club statistician Ged Rea, read on...
This will be Liverpool's first visit to the Tottenham Hotspur Stadium.
The Reds are three goals short of recording 150 in all league games against Spurs.
Liverpool have netted 94 Premier League goals against Tottenham. Only against Newcastle United (101) have they scored more.
In 11 games in all competitions against Spurs, Klopp has won six and drawn four with a single defeat.
Mohamed Salah has scored five times in his six appearances against Tottenham, with four coming in the league. He has seven goals in nine career starts against the Londoners.
There have been 158 goals scored in Premier League games involving the two teams. Only against Arsenal (159) have there been more in Liverpool fixtures.
LFC's biggest-ever victory at Tottenham came in December 2013 when they won 5-0. Of the 18 players involved that day only Jordan Henderson is still at Anfield.
Liverpool have scored two goals in each of the last five meetings with Saturday's opponents in league and cup.
The Reds have lost only one of the last 14 meetings in the top flight (4-1 at Wembley in 2017) and one in 16 in all competitions.
Klopp's men are undefeated in 37 league games. Only three teams have ever gone on a longer run in the top flight – Arsenal 49 (2003-04), Nottingham Forest 42 (1977-78) and Chelsea 40 (2004-05).
The Reds are looking for a second successive league double over Spurs as they won both fixtures last season (2-1), including the victory at Wembley when Georginio Wijnaldum scored his first away league goal for Liverpool.