The No.10 is one of two changes made by Jürgen Klopp for the last-16, first-leg clash at Estadio Metropolitano.
The other sees Fabinho named in midfield, with Naby Keita and Alex Oxlade-Chamberlain dropping to the bench.
Liverpool: Alisson, Alexander-Arnold, Gomez, Van Dijk, Robertson, Fabinho, Henderson, Wijnaldum, Mane, Salah, Firmino.
Subs: Adrian, Milner, Keita, Oxlade-Chamberlain, Minamino, Origi, Matip.