The captain returns to the line-up three weeks after sustaining a hamstring injury in the first leg of the last-16 meeting.
Henderson replaces Fabinho in the Reds’ starting XI in one of two changes, with the other seeing Andy Robertson return at left-back.
Liverpool: Adrian, Alexander-Arnold, Gomez, Van Dijk, Robertson, Henderson, Wijnaldum, Oxlade-Chamberlain, Mane, Salah, Firmino.
Subs: Lonergan, Fabinho, Milner, Minamino, Lallana, Origi, Matip.