The champions travel to St. James' Park on Sunday seeking a 32nd top-flight win of an historic campaign - and victory would see them set another new club record by ending 2019-20 on 99 points.
Captain Jordan Henderson (knee) and centre-back Joel Matip (foot) had already been ruled out for the remainder of the season, but Klopp did not mention any fresh fitness worries during his pre-match press conference.
Meanwhile, providing a squad update during his media briefing on Friday, Newcastle boss Steve Bruce said: “We might have Isaac Hayden and Sean Longstaff available.
“We’ve got a problem with Emil Krafth, who took a nasty whack to his ankle so we’ll see how he is over the next 24 hours.
“Unfortunately we won't have any of the defenders back. We've got six centre-backs on the books and five of them are injured [and] the one stand-in we put there is injured too.”
Kell Watts was on the bench for Newcastle's goalless draw with Brighton and Hove Albion last time out and the 20-year-old defender could make his debut for the club this weekend.
Bruce also paid tribute to the newly-crowned champions.
“When you look at their team, and the squad of players they’ve put together, they’re young, and they could be around for a long, long time... you can only just applaud them,” he noted.
“To be 20-odd points clear... they practically won the league before lockdown. It’s a quite remarkable achievement, so congratulations to them all. They’re a breath of fresh air.”
Last match
Brighton 0-0 Newcastle United (July 20): Dubravka, Manquillo, Krafth, Fernandez, Rose, Bentaleb, Shelvey, Ritchie, Saint-Maximin, Almiron, Gayle.
Liverpool 5-3 Chelsea (July 22): Alisson, Alexander-Arnold, Gomez, Van Dijk, Robertson, Fabinho, Wijnaldum, Keita, Mane, Salah, Firmino.