A total of 2,000 fans are set to be in attendance at the historic stadium for the weekend's Premier League encounter with Jota's former side Wolverhampton Wanderers.
Having made the switch from Molineux to Merseyside in September, the Portugal forward has only represented the Reds at L4 in behind-closed-doors fixtures.
Therefore, he's looking forward to the prospect of a new experience come 7.15pm GMT on Sunday.
Speaking to Sky Sports, the No.20 said: "Football without fans is strange.
“Obviously when you play for a club like Liverpool that has one of the best atmospheres in the world, it just feels like something is missing.
"We have a lot of these conversations with the staff and even with the players [on] the things I am missing.
"Feeling the Anfield effect is the thing I'm looking forward [to] most."