The 19-year-old Academy graduate lines up in midfield at the Arena Herning to claim his third appearance for the Reds’ senior side.
Jürgen Klopp makes a total of eight changes in Denmark, with Trent Alexander-Arnold and Naby Keita returning to the starting XI.
Only Caoimhin Kelleher, Fabinho and Mohamed Salah retain their places from Sunday’s win over Wolverhampton Wanderers.
Liverpool: Kelleher, Alexander-Arnold, R. Williams, Fabinho, Tsimikas, Clarkson, Keita, Minamino, Jota, Origi, Salah.
Subs: Adrian, Jaros, Wijnaldum, Firmino, Mane, Henderson, Jones, Robertson, Matip, Cain, N. Williams, Koumetio.