The Reds progressed to the tournament’s knockout stages for the fourth successive season by topping Group D ahead of Atalanta BC, AFC Ajax and FC Midtjylland.
Jürgen Klopp’s side are therefore seeded for the draw, which will take place from 11am GMT at UEFA’s headquarters in Nyon, Switzerland and be streamed live on UEFA.com.
Liverpool will be paired with one of the following seven runners-up in the group phase: Atletico Madrid, Borussia Monchengladbach, FC Porto, Sevilla, SS Lazio, FC Barcelona, RB Leipzig.
Seeded teams play the first leg of their last-16 tie away from home.
Match dates are scheduled for February 16/17/23/24 (first legs) and March 9/10/16/17 (second legs) with all games kicking off at 8pm UK time.