The 19-year-old centre-back replaces Joel Matip, who is ruled out due to a back spasm, in the starting line-up.
It’s the only change the Reds make to the team deployed at Fulham on Sunday; however, Naby Keita returns to the squad and is named on the bench.
Liverpool: Alisson, Alexander-Arnold, R. Williams, Fabinho, Robertson, Henderson, Wijnaldum, Jones, Mane, Salah, Firmino.
Subs: Kelleher, Keita, Oxlade-Chamberlain, Minamino, Origi, Phillips, N. Williams.